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Pantoprazole.

P Poole1

  • 1Department of Pharmaceutical Services, University of California Davis Medical Center, Sacramento, CA, USA.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|June 14, 2001
PubMed
Summary
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Pantoprazole, a proton-pump inhibitor, effectively treats acid-related disorders like erosive esophagitis and ulcers. It is well-tolerated with common side effects including headache and diarrhea.

Area of Science:

  • Pharmacology
  • Gastroenterology

Background:

  • Pantoprazole is a gastric hydrogen-potassium adenosine triphosphatase (H+/K(+)-ATPase) inhibitor, similar to other proton-pump inhibitors (PPIs).
  • Its primary FDA-labeled indication is for the short-term treatment of erosive esophagitis.

Purpose of the Study:

  • To review the pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage of pantoprazole.
  • To compare pantoprazole's safety and efficacy with other PPIs in managing acid-related disorders.

Main Methods:

  • Review of over 100 clinical trials involving more than 11,000 patients.
  • Analysis of pantoprazole's absorption, metabolism, bioavailability, and mechanism of action.

Main Results:

  • Pantoprazole is effective for erosive esophagitis, duodenal and gastric ulcers, and as adjunctive therapy for H. pylori infections.

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  • It demonstrates efficacy in controlling acid production in Zollinger-Ellison syndrome.
  • The drug is well-tolerated, with headache, diarrhea, and abdominal pain being the most frequent adverse effects.

    • Conclusions:

    • Pantoprazole is a safe and effective option for managing various acid-related gastrointestinal disorders.
    • Its pharmacodynamics, particularly the rate of proton-pump regeneration, are more critical than pharmacokinetics for its duration of action.
    • Recommended dosages include 40 mg daily orally for erosive esophagitis and 40 mg intravenously for patients unable to take oral medication.