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Updated: Oct 7, 2026

Whole Mount Imaging to Visualize and Quantify Peripheral Lens Structure, Cell Morphology, and Organization
Published on: January 19, 2024
[Scanning microscopy and immunohistochemical studies of an explanted phacic posterior chamber lens (ICL-M, STAAR)]
R Keuch1, N Schnoy, H Bleckmann
1Augenabteilung der Schlosspark-Klinik Berlin, Heubnerweg 2, 14059 Berlin.
Objective:
This study was performed to find out if an explanted phacic collamer IOL (ICL/STAAR) showed structural or surface quality changes after an intraocular implantation.
Material And Methods:
We explanted an ICL 6 months after implantation and compared it to a new reference lens using scanning electron microscopy and immunohistochemical investigations.
Results:
The explanted ICL showed no changes in comparison to a new ICL except for a coating with an unidentified material. Both the new and explanted ICL presented grooves on the surface and superficial holes of unknown origin measuring roughly 10 mu. Neither pigment nor macrophages could be found on the explanted lens. Although the lens material contained 0.1% collagen, the immunohistochemical staining for collagen was negative.
Conclusions:
The collagen content of the ICL could not be proven using immunohistochemistry. No changes were found between the new and the explanted lens, except for a coating of the explanted lens with an unidentified material.
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