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Concomitant papillary thyroid carcinoma and Hashimoto's thyroiditis.
L H Liu1, R Bakhos, E M Wojcik
1Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA.
Seminars in Diagnostic Pathology
|June 14, 2001
Summary
Fine needle aspiration (FNA) accuracy for diagnosing papillary thyroid carcinoma (PTC) alongside Hashimoto
Area of Science:
- Endocrinology
- Cytopathology
- Oncology
Background:
- Papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) frequently coexist.
- Morphologic overlap between PTC and HT can complicate diagnosis.
Purpose of the Study:
- To assess the diagnostic accuracy of fine needle aspiration (FNA) for identifying concurrent PTC and HT.
- To evaluate challenges in cytologic diagnosis when PTC and HT are present together.
Main Methods:
- Retrospective review of 29 thyroid FNA cases with confirmed concomitant PTC and HT.
- Cytologic specimens were analyzed for diagnostic features of both PTC and HT.
Main Results:
- PTC was diagnosed or suggested in 16 of 29 cases, but both entities were identified in only 3 cases.
- Interpretation and sampling errors contributed to missed or uncertain diagnoses, with 10 cases initially misclassified.
Conclusions:
- Awareness of the co-occurrence of PTC and HT is crucial for improving FNA diagnostic accuracy.
- Cytologic diagnosis of follicular variant PTC with HT is challenging and prone to false-negative results due to sampling errors.