Related Experiment Video
Updated: Oct 7, 2026

Circadian Entrainment of Drosophila Melanogaster
Published on: June 3, 2020
Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm
H R Ueda1, M Hagiwara, H Kitano
1ERATO Kitano Symbiotic Systems Group, Suite 6A, M31, 6-31-15 Jinguumae, Shibuya, Tokyo, 150-0001, Japan. hiro@m.u-tokyo.ac.jp
Abstract:
A mechanism for generating circadian rhythms has been of major interest in recent years. After the discovery of per and tim, a model with a simple feedback loop involving per and tim has been proposed. However, it is recognized that the simple feedback model cannot account for phenotypes generated by various mutants. A recent report by Glossop, Lyons & Hardin [Science286, 766 (1999)] on Drosophila suggests involvement of another feedback loop by dClk that is interlocked with per-tim feedback loop. In order to examine whether interlocked feedback loops can be a basic mechanism for circadian rhythms, a mathematical model was created and examined. Through extensive simulation and mathematical analysis, it was revealed that the interlocked feedback model accounts for the observations that are not explained by the simple feedback model. Moreover, the interlocked feedback model has robust properties in oscillations.
Related Concept Videos
Circadian Rhythms and Gene Regulation
Circadian Rhythms and Gene Regulation
Damped Oscillations
Although friction and other non-conservative...
Oscillations about an Equilibrium Position
Biological Clocks and Seasonal Responses
Forced Oscillations
