Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Change in vasoconstrictive function during prolonged nonpulsatile left heart bypass.

T Nishinaka1, E Tatsumi, T Nishimura

  • 1Department of Artificial Organs, National Cardiovascular Center Research Institute, Osaka, Japan.

Artificial Organs
|June 14, 2001
PubMed
Summary

Prolonged nonpulsatile left heart bypass (NLHB) significantly reduced vasoconstrictive function. This indicates a diminished vascular response to medications like phenylephrine after extended NLHB.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Formation and evolution of carbonaceous asteroid Ryugu: Direct evidence from returned samples.

Science (New York, N.Y.)·2022
Same author

Pebbles and sand on asteroid (162173) Ryugu: In situ observation and particles returned to Earth.

Science (New York, N.Y.)·2022
Same author

Variations in color and reflectance on the surface of asteroid (101955) Bennu.

Science (New York, N.Y.)·2020
Same author

Sample collection from asteroid (162173) Ryugu by Hayabusa2: Implications for surface evolution.

Science (New York, N.Y.)·2020
Same author

An artificial impact on the asteroid (162173) Ryugu formed a crater in the gravity-dominated regime.

Science (New York, N.Y.)·2020
Same author

Journal of Artificial Organs 2019: the year in review : Journal of Artificial Organs Editorial Committee.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2020

Area of Science:

  • Cardiovascular Physiology
  • Medical Device Technology

Background:

  • Left heart bypass (LHB) is used in cardiac support.
  • Understanding the impact of pulsatile versus nonpulsatile flow on vascular function is crucial.

Purpose of the Study:

  • To investigate the effects of prolonged nonpulsatile left heart bypass (NLHB) on systemic vasoconstrictive function.
  • To compare the vascular response to phenylephrine after NLHB versus continued pulsatile left heart bypass (PLHB).

Main Methods:

  • Goats underwent 2 weeks of PLHB, followed by 4 weeks of either NLHB (Group N) or continued PLHB (Group P).
  • Systemic vascular resistance (SVR) was measured at rest (rSVR) and after phenylephrine injection (SVRmax, DeltaSVR) at postoperative weeks 2 and 6.

Main Results:

Related Experiment Videos

  • No significant differences in rSVR were observed between groups at week 2 or week 6.
  • Vascular responses (SVRmax, DeltaSVR) to phenylephrine were similar at week 2.
  • At week 6, Group N (NLHB) showed significantly lower SVRmax and DeltaSVR compared to Group P (PLHB).

Conclusions:

  • Prolonged NLHB leads to a significant decrease in vasoconstrictive function.
  • The diminished vascular response suggests impaired smooth muscle function or altered receptor sensitivity after NLHB.