Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hormonal changes in aging men: a therapeutic indication?

M Hermann1, P Berger

  • 1Institute for Biomedical Aging Research, Austrian Academy of Sciences, Endocrinology Unit, Rennweg 10 A-6020 Innsbruck, Austria.

Experimental Gerontology
|June 19, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical relevance of circulating blood microaggregates and reactivation of Epstein Barr Virus in long-term Post-CoVID syndrome patients.

Scientific reports·2026
Same author

Estimating the prevalence of mental disorders in patients with newly diagnosed cancer in relation to socioeconomic status: a multicenter prospective observational study.

ESMO open·2024
Same author

Circulating microaggregates as biomarkers for the Post-COVID syndrome.

IDCases·2024
Same author

Live stream of prehospital point-of-care ultrasound during cardiopulmonary resuscitation - A feasibility trial.

Resuscitation·2023
Same author

Apparent limitations of OECD TG 431 for classification of acrylic- and methacrylic-based adhesives.

Toxicology in vitro : an international journal published in association with BIBRA·2023
Same author

Balloon-Atrioseptostomy in Small Children Using an Embolectomy Catheter: Preliminary Data.

Case reports in cardiology·2023

Aging men experience symptoms like muscle weakness and fatigue due to hormonal changes. Hormone replacement therapy shows limited benefits for aging men, requiring more research for effective treatments.

Area of Science:

  • Endocrinology
  • Gerontology
  • Men's Health

Background:

  • Male life expectancy is increasing, accompanied by age-related symptoms impacting quality of life.
  • Symptoms include muscle weakness, osteoporosis, fatigue, and erectile dysfunction, mirroring hormone deficiencies.
  • Three key male endocrine axes (testicular, adrenal, GH/IGF-I) show age-related hormonal decline.

Purpose of the Study:

  • To evaluate the potential of hormone replacement therapy (HRT) in mitigating symptoms of male aging.
  • To address the challenges in HRT for aging men, including lack of reference values and clinical read-out parameters.

Main Methods:

  • Review of age-related changes in male endocrine axes and hormone levels.
  • Assessment of existing evidence on hormone replacement in hormone-deficient individuals and postmenopausal women.

Related Experiment Videos

  • Analysis of the applicability and limitations of HRT for aging men.

    • Main Results:

    • Hormone replacement shows promise but faces hurdles due to a lack of individualized hormone reference values.
    • Current findings do not support widespread HRT for elderly men.
    • Reliable clinical parameters are needed to demonstrate functional benefits of HRT.

    Conclusions:

    • Widespread hormone replacement is not currently recommended for aging men.
    • Further large-scale, long-term studies are essential.
    • Identifying effective clinical read-out parameters is crucial to establish individual treatment benefits for aging men.