Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human aging and melatonin. Clinical relevance.

Y Touitou1

  • 1Department of Biochemistry, Faculty of Medicine Pitié-Salpétrière, 91 Boulevard de l'Hôpital, 75634 Paris Cedex 13, France. touitou@ccr.jussieu.fr

Experimental Gerontology
|June 19, 2001
PubMed
Summary

Melatonin, a hormone primarily secreted at night, influences the sleep-wake cycle. Its administration timing is crucial for managing sleep disorders like delayed sleep phase syndrome and jet lag.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Predatory journals, a threat not to be neglected].

Annales pharmaceutiques francaises·2019
Same author

[The circadian system in man: From the internal clock to melatonin secretion].

Annales pharmaceutiques francaises·2016
Same author

Commemoration Erhard Haus, M.D., Ph.D.

La Clinica terapeutica·2013
Same author

Light pulse induces ALA-S gene expression in the rat Harderian gland.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2010
Same author

Chronobiological aspects of food intake and metabolism and their relevance on energy balance and weight regulation.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2010
Same author

Desynchronization of daily rest-activity rhythm in the days following light propofol anesthesia for colonoscopy.

Clinical pharmacology and therapeutics·2008

Area of Science:

  • Endocrinology
  • Chronobiology
  • Sleep Medicine

Background:

  • Melatonin is a pineal gland hormone with peak nocturnal levels.
  • Melatonin levels naturally decline with age after peaking in early childhood.
  • It functions as a chronobiotic, regulating the sleep-wake cycle.

Purpose of the Study:

  • To explore the role of melatonin in regulating sleep-wake cycles.
  • To investigate the therapeutic applications of melatonin in sleep disorders.
  • To examine melatonin's effects in conditions like jet lag and shift work disorder.

Main Methods:

  • Observational analysis of melatonin secretion patterns.
  • Clinical studies on melatonin administration for sleep phase disorders.
  • Evaluation of melatonin's efficacy in circadian rhythm disruption.

Main Results:

  • Melatonin administration can phase-advance or delay the sleep-wake cycle.
  • Beneficial effects observed in delayed and advanced sleep phase syndromes.
  • Melatonin shows potential for managing jet lag and shift work-related desynchronization.

Conclusions:

  • Melatonin is a key regulator of circadian rhythms and sleep.
  • Timing of melatonin administration is critical for therapeutic success.
  • Further research supports melatonin's role in sleep and circadian rhythm management.

Related Experiment Videos