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Related Experiment Video

Updated: Jul 21, 2026

Methodology for Sputum Induction and Laboratory Processing

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Laboratory protocol for exercise asthma to evaluate salbutamol given by two devices.

S D Anderson¹, S Lambert, J D Brannan

¹Department of Respiratory Medicine, Page Chest Pavilion, Royal Prince Alfred Hospital, Missenden Road, Camperdown NSW 2050 Australia. sandya@mail.med.usyd.edu.au

Medicine and Science in Sports and Exercise

|June 19, 2001

Summary

New inhaler devices for salbutamol (an asthma medication) are equivalent to older ones in preventing exercise-induced asthma (EIA). This study validates a protocol for comparing asthma drug delivery systems.

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Area of Science:

Respiratory Medicine
Pharmacology
Clinical Trials

Background:

New inhalation devices and formulations require equivalence testing against established preparations.
Evaluating protection against exercise-induced asthma (EIA) is a key method for assessing drug equivalence.

Purpose of the Study:

To compare the efficacy of salbutamol delivered via a Diskus dry powder device versus a traditional metered-dose inhaler (pMDI) in preventing EIA.
To validate a standardized protocol for assessing the equivalence of inhaled asthma medications.

Main Methods:

A protocol for EIA was employed, comparing salbutamol via Diskus and pMDI in 27 asthmatic subjects.
Subjects underwent an exercise challenge (8-min cycling in dry air) after receiving placebo or active treatment.
Lung function (FEV1) was measured to quantify EIA severity, with workload, ventilation, and heart rate standardized.

Main Results:

No significant differences were observed in workload, ventilation, or heart rate between study days.
Salbutamol significantly inhibited EIA, as measured by the percentage fall in FEV1.
There was no statistically significant difference in EIA protection between the Diskus and pMDI formulations of salbutamol.

Conclusions:

The developed EIA protocol is suitable for evaluating the equivalence of different salbutamol preparations.
This methodology can be applied to assess the protective effects of other inhaled medications for asthma.