Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Assessing tablet bond types from structural features that affect tablet tensile strength.

H Olsson1, C Nyström

  • 1Department of Pharmacy, Uppsala University, Sweden.

Pharmaceutical Research
|June 19, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurements of the natural background of radioxenon isotopes in soil gas.

Journal of environmental radioactivity·2025
Same author

Cohort profile: The Swedish Tattoo and Body Modifications Cohort (TABOO).

BMJ open·2023
Same author

Do we need a pandemic to improve hygiene routines in the ambulance service? A cross-sectional study.

International emergency nursing·2022
Same author

Low sun exposure habits is associated with a dose-dependent increased risk of hypertension: a report from the large MISS cohort.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2021
Same author

Are low sun exposure habits a genuine strong risk factor for all-cause mortality or the result of bias?

Journal of internal medicine·2017
Same author

Risk of second primary cancer in patients treated with radiotherapy for rectal cancer.

The British journal of surgery·2016

This study assessed tablet structural features influencing tensile strength to identify bond types. Porosity and particle size were key factors, providing insights into interparticulate attractions in tablets.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Physical Chemistry

Background:

  • Tablet tensile strength is a critical quality attribute in pharmaceutical manufacturing.
  • Understanding interparticulate bonding is essential for predicting tablet performance.
  • Existing methods for assessing bond types can be complex and time-consuming.

Purpose of the Study:

  • To investigate the correlation between structural features and tablet tensile strength.
  • To develop a method for assessing dominating bond types within tablets based on structural analysis.
  • To evaluate the applicability of this assessment method across various materials.

Main Methods:

  • Tablets were prepared from seven different materials: potassium chloride, sodium chloride, sodium bicarbonate, lactose, sucrose, microcrystalline cellulose, and ascorbic acid.

Related Experiment Videos

  • Key structural features, including tablet porosity and particle size (external specific surface area by permeametry), were measured.
  • A tablet model was employed to assess these structural features in relation to tablet tensile strength.

    • Main Results:

    • Tablet porosity and particle size demonstrated the strongest correlation with tablet tensile strength.
    • A 'structural factor' was derived from these features.
    • An 'interaction factor,' combining the structural factor and tensile strength, effectively reflected the dominating bond types in the tablets.

    Conclusions:

    • The developed method successfully identified dominating bond types in the studied tablets.
    • The qualitative findings align with previous research, validating the method's applicability.
    • This approach offers a valuable tool for understanding and predicting tablet behavior based on structural properties.