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A novel [60]fullerene amino acid for use in solid-phase peptide synthesis
F Pellarini1, D Pantarotto, T Da Ros
1Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa, 1, 34127 Trieste, Italy, and Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Università di Trieste, Via Giorgieri 1, 34127 Trieste, Italy.
Abstract:
[see structure]. A fullerene derivative containing a free amino group has been condensed with N-Fmoc-L-glutamic acid alpha-tert-butyl ester to give a C60-functionalized amino acid. The carboxylic end of this amino acid has been deprotected in acidic conditions, and the resulting acid has been used for solid-phase peptide synthesis. The final peptide, cleaved from the resin, was very soluble in water solutions and showed antimicrobial activity against two representative bacteria.