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Formal synthesis of uvaricin via palladium-mediated double cyclization
1Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706-1396, USA. burke@chem.wisc.edu
Organic Letters
|June 19, 2001
Abstract:
[see reaction]. A novel palladium-mediated, ligand-controlled double cyclization is reported. The C2-symmetric diene produced was desymmetrized via Sharpless asymmetric dihydroxylation and was further transformed into a known intermediate in the synthesis of uvaricin.