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Trypanosome and animal lanosterol synthases use different catalytic motifs
B M Joubert1, F S Buckner, S P Matsuda
1Department of Chemistry, Rice University, 6100 South Main Street, Houston, Texas 77005, USA.
Organic Letters
|June 19, 2001
Abstract:
[see reaction]. Animals, fungi, and some protozoa convert oxidosqualene to lanosterol in the ring-forming reaction in sterol biosynthesis. The Trypanosoma cruzi lanosterol synthase has now been cloned. The sequence shares with the T. brucei lanosterol synthase a tyrosine substitution for the catalytically important active-site threonine found in animal and fungal lanosterol synthases.