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Related Experiment Videos

Ocular findings in anencephaly.

V Boniuk, P K Ho

    American Journal of Ophthalmology
    |September 1, 1979
    PubMed
    Summary

    An anencephalic infant presented with an upper eyelid notch and posterior pole lens. The developmental insult likely occurred during the fifth to tenth week of gestation.

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    Area of Science:

    • Developmental biology
    • Ophthalmology
    • Teratology

    Background:

    • Anencephaly is a severe congenital disorder characterized by the absence of a major portion of the brain, skull, and scalp.
    • Understanding the timing and nature of developmental insults is crucial for identifying causes of congenital anomalies.

    Observation:

    • A newborn infant diagnosed with anencephaly exhibited an upper eyelid notch.
    • A posterior pole lens anomaly was also noted in the same infant.

    Findings:

    • Analysis of the affected ocular tissues suggests the developmental insult occurred between the fifth and tenth weeks of gestation.
    • The timing points towards a critical period of ocular and central nervous system development.

    Implications:

    • This case provides insight into the potential timing of developmental disruptions leading to complex congenital malformations.
    • Further research can explore the specific etiological factors impacting early gestation and their link to anencephaly and associated anomalies.

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