Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute changes in bronchoconstriction influences exhaled nitric oxide level.

H Mitsufuji1, H Kobayashi, T Imasaki

  • 1Department of Medicine, Kitasato University School of Medicine, Sagamihara, 228-8555 Japan.

The Japanese Journal of Physiology
|June 19, 2001
PubMed
Summary

Bronchoconstriction affects exhaled nitric oxide (NO) levels in asthma patients, independent of inflammation. Airway constriction traps NO, which is released upon bronchodilation, altering measured levels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Expandable metallic stent therapy for SVC syndrome--effects on local venous pressure, vascular diameter, symptoms, and these correlations].

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·1992
Same author

[Biological effects of static gradient magnetic field on cultured mammalian cells and combined effects with 60Co gamma-rays].

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·1992
Same author

Bleomycin but not its derivatives inhibits the in vivo shedding of a rat tumor-associated antigen.

Anti-cancer drugs·1992
Same author

Isolation of cDNA for bovine stomach 155 kDa protein exhibiting myosin light chain kinase activity.

Journal of biochemistry·1992
Same author

Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH.

Journal of bacteriology·1992
Same author

Cooperative modulation of voltage-dependent sodium channels by brevetoxin and classical neurotoxins in cultured bovine adrenal medullary cells.

The Journal of pharmacology and experimental therapeutics·1992

Area of Science:

  • Respiratory Medicine
  • Pulmonary Physiology
  • Biomedical Engineering

Background:

  • Exhaled nitric oxide (NO) is a marker for airway inflammation in asthma.
  • Previous studies focused on inflammation's role, neglecting bronchoconstriction's impact on exhaled NO.

Purpose of the Study:

  • To investigate the influence of acute bronchoconstriction and bronchodilation on exhaled NO levels.
  • To differentiate the effects of airway caliber changes from inflammation on exhaled NO.

Main Methods:

  • Healthy volunteers and asthma patients inhaled a bronchoconstrictor (methacholine) or bronchodilator (salbutamol).
  • Exhaled NO levels were measured before and after inhalation.
  • Asthma patients during attacks received salbutamol and aminophylline infusion.

Related Experiment Videos

Main Results:

  • Methacholine inhalation decreased exhaled NO in healthy volunteers.
  • Salbutamol inhalation increased exhaled NO in mild/moderate persistent asthma patients without attacks.
  • Exhaled NO increased in asthma patients during attacks after salbutamol and aminophylline.

Conclusions:

  • Acute changes in bronchoconstriction significantly influence exhaled NO levels.
  • NO trapping in constricted airways may explain decreased exhalation.
  • Bronchodilation increases exhaled NO, suggesting release of trapped NO, independent of NO synthase activity changes.