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Related Experiment Videos

Dehydroepiandrosterone (DHEA) supplementation for cognitive function .

F A Huppert1, J K Van Niekerk

  • 1Department of Psychiatry, University of Cambridge, Box 189, Addenbrooke's Hospital, Cambridge, UK, CB22 2QQ. fah2@cus.cam.ac.uk

The Cochrane Database of Systematic Reviews
|June 19, 2001
PubMed
Summary
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Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) supplementation showed no significant cognitive benefits in older adults or those with dementia. Further long-term, high-quality trials are needed to explore potential neuroprotective effects.

Area of Science:

  • Neuroscience and Aging Research
  • Endocrinology and Cognitive Function

Background:

  • Theoretical basis suggests dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) may benefit cognitive function in aging and dementia.
  • Widespread public use of DHEA supplements necessitates scientific investigation into efficacy, dosage, and safety.

Purpose of the Study:

  • To determine if DHEA or DHEAS administration improves cognitive function in healthy older adults or individuals with dementia.
  • To assess if DHEA/S reduces the rate of cognitive decline in these populations.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) investigating DHEA/S effects on cognition in older adults.
  • Independent data extraction by two reviewers; no meta-analysis due to insufficient statistical data.
  • Inclusion of studies on normal aging and cognitive decline; no studies specifically on dementia were found.

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Main Results:

  • One study indicated improved visual memory recall in women after 2 weeks of DHEA, but no effects in men or on verbal memory.
  • Another study showed DHEA mitigated attention decline after stress but impaired visual memory post-stress; no effects without stress.
  • A third study found no significant cognitive effects of DHEA compared to placebo after 3 months; DHEA was generally well-tolerated.

Conclusions:

  • Current data do not support DHEA treatment for improving memory or cognitive function in older adults.
  • High-quality, long-term trials (over one year) with sufficient participants are required to detect potential neuroprotective effects.
  • Results from recently completed trials in various populations are pending and will be incorporated into future reviews.