Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Colloid solutions for fluid resuscitation.

F Bunn1, P Alderson, V Hawkins

  • 1Public Health Intervention Research Unit, London School of Hygiene & Tropical Medicine, 49-51 Bedford Square, London, UK, WC1B 3DP. Frances.Bunn@lshtm.ac.uk

The Cochrane Database of Systematic Reviews
|June 19, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prophylaxis guidelines: Repeated points.

British dental journal·2016
Same author

Prophylaxis guidelines: Repeated points.

British dental journal·2016
Same author

Expression of Kir4.1 and Kir5.1 inwardly rectifying potassium channels in oligodendrocytes, the myelinating cells of the CNS.

Brain structure & function·2016
Same author

Is there a link between overactive bladder and the metabolic syndrome in women? A systematic review of observational studies.

International journal of clinical practice·2014
Same author

Systematic review and meta-analysis of enhanced recovery programmes in surgical patients.

The British journal of surgery·2014
Same author

Economic modelling of diagnostic and treatment pathways in National Institute for Health and Care Excellence clinical guidelines: the Modelling Algorithm Pathways in Guidelines (MAPGuide) project.

Health technology assessment (Winchester, England)·2013
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
Same journal

Non-pharmacological interventions for anxiety and depression in Parkinson's disease.

The Cochrane database of systematic reviews·2026
Same journal

Biologic drugs for induction and maintenance of remission in Crohn's disease: a network meta-analysis.

The Cochrane database of systematic reviews·2026
Same journal

Preconception and first-trimester metformin for improving pregnancy outcomes in women with polycystic ovary syndrome.

The Cochrane database of systematic reviews·2026
See all related articles

This review found no evidence that different colloid solutions vary in safety or efficacy for fluid replacement. Larger trials are needed to detect potential clinical differences in colloid solutions.

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Clinical Trials

Background:

  • Colloid solutions are frequently used for fluid volume replacement.
  • Concerns exist regarding the benefits and safety of various colloid solutions.
  • Colloids differ in molecular weight, circulatory half-life, and other characteristics influencing their efficacy and safety.

Purpose of the Study:

  • To compare the effects of different colloid solutions in patients requiring volume replacement.
  • Evaluate safety and efficacy of various colloid formulations.

Main Methods:

  • Systematic review of randomized and quasi-randomized trials.
  • Searched Cochrane Injuries Group register, Cochrane Controlled trials register, MEDLINE, and EMBASE (up to 2000).
  • Included critically ill and surgical patients; outcomes: mortality, blood transfusion, adverse reactions.

Related Experiment Videos

Main Results:

  • 52 trials with 3311 participants were included.
  • No significant differences in mortality were found between albumin/plasma protein fraction (PPF) vs. hydroxyethyl starch (HES), albumin/PPF vs. gelatin, or gelatin vs. HES.
  • Confidence intervals were wide, not excluding clinically significant differences; quantitative analysis of blood transfused and adverse reactions was limited.

Conclusions:

  • Current evidence does not demonstrate superiority of one colloid solution over another in terms of safety or efficacy.
  • Wide confidence intervals indicate the need for further research.
  • Larger, well-designed fluid therapy trials are necessary to detect or exclude clinically significant differences in mortality.