Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Differential membrane fluidization by active and inactive cannabinoid analogues.

T Mavromoustakos1, D Papahatjis, P Laggner

  • 1Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens, Greece. tmavro@eie.gr

Biochimica Et Biophysica Acta
|June 19, 2001
PubMed
Summary

The more active cannabinoid drug AMG-3 significantly altered DPPC liposome properties, while its less active analogue AMG-18 had minimal effects, suggesting a link between these structural changes and biological activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydrogels containing water soluble conjugates of silver(I) ions with amino acids, metabolites or natural products for non infectious contact lenses.

Dalton transactions (Cambridge, England : 2003)·2021
Same author

Organotin derivatives of cholic acid induce apoptosis into breast cancer cells and interfere with mitochondrion; Synthesis, characterization and biological evaluation.

Steroids·2021
Same author

pHEMA@AGMNA-1: A novel material for the development of antibacterial contact lens.

Materials science & engineering. C, Materials for biological applications·2020
Same author

An Efficient Disinfectant, Composite Material {SLS@[Zn<sub>3</sub>(CitH)<sub>2</sub>]} as Ingredient for Development of Sterilized and Non Infectious Contact Lens.

Antibiotics (Basel, Switzerland)·2019
Same author

Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand.

Platelets·2017
Same author

Docking and Molecular Dynamics Calculations of Pyrrolidinone Analog MMK16 Bound to COX and LOX Enzymes.

Molecular informatics·2016

Area of Science:

  • Biophysics
  • Pharmacology
  • Lipid Bilayer Research

Background:

  • Cannabinoid-like drugs interact with biological systems.
  • Understanding their effects on cell membrane models is crucial.

Purpose of the Study:

  • To investigate the impact of two cannabinomimetic drugs (AMG-3 and AMG-18) on DPPC liposome properties.
  • To correlate observed structural and thermotropic changes with drug activity.

Main Methods:

  • Differential Scanning Calorimetry (DSC) to analyze thermal transitions.
  • X-ray diffraction (small and wide angle) to study structural changes.
  • Investigated dipalmitoyl-sn-glycero-3-phosphorylcholine (DPPC) liposomes.

Main Results:

Related Experiment Videos

  • The active drug AMG-3 significantly broadened and attenuated DPPC phase transitions and perturbed lipid packing.
  • The less active AMG-18 showed only minor effects at equivalent concentrations.
  • Higher concentrations of AMG-18 produced less pronounced effects compared to AMG-3.

    • Conclusions:

    • Pharmacologically active AMG-3 markedly affects DPPC liposome thermotropic and structural properties.
    • The observed dose-dependent differences in effects between AMG-3 and AMG-18 suggest a correlation with their biological activity.
    • Cannabinoid structure influences lipid bilayer organization and dynamics.