Related Experiment Video
Updated: Aug 6, 2026

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus
Published on: March 28, 2017
The Aspergillus nidulans metE gene is regulated by a second system independent from sulphur metabolite repression
M Grynberg1, M Piotrowska, E Pizzinini
1Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Abstract:
Mutations in the Aspergillus nidulans metE gene lead to requirement for O-acetylhomoserine. The gene was cloned by complementation of the metE31 mutation. The coding sequence was found to be interrupted by two introns of 66 and 50 bp, respectively. metE codes for a peptide of 489 amino acids which belongs to the family of homoserine O-acetyltransferases and a well-defined superfamily of alpha/beta hydrolases. Transcription of the metE gene is strongly up-regulated by a severe limitation of methionine, but not of cysteine. This gene is the first sulphur metabolism gene described in A. nidulans which is not regulated by the sulphur metabolite repression system in which cysteine acts as the low-molecular-weight effector.
More Related Videos
Related Concept Videos
Prokaryotic Transcriptional Activators and Repressors
Transcription of prokaryotic...
Regulation of Metabolism
Global Regulatory Systems
Gene Regulation in Microbial Communities: Quorum Sensing
Gene Regulation During Sporulation
Regulation of Bacterial Virulence

