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Methamphetamine increases expression of the apoptotic c-myc and L-myc genes in the mouse brain
N Thiriet1, S Jayanthi, M McCoy
1Molecular Neuropsychiatry Section, National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD 21224, USA.
Brain Research. Molecular Brain Research
|June 19, 2001
Abstract:
To clarify the possible mechanisms by which the recreational drug, methamphetamine (METH), induces apoptosis, we investigated its effects on the expression of Myc apoptotic genes. This paper presents the characterization of c-myc and L-myc gene transcription in the striatum and the cortex. In addition, the expression of the corresponding proteins was also evaluated. Our observations reveal that c-myc and L-myc were up-regulated by METH at both the mRNA and protein levels. Thus, myc transcription factors might be responsible for some aspects of METH-induced apoptotic processes.