NMR methodology for the study of nucleic acids
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Updated: Oct 7, 2026

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Published on: February 9, 2024
1National Centre for Biomolecular Research, Masaryk University, Kotlárská 2, 611 37, Brno, Czech Republic.
Abstract:
During the past few years, NMR methodology for the study of nucleic acids has benefited from new developments that greatly improved state-of-the-art technology for the precise determination of three-dimensional structures. Substantial progress has been made in designing experimental protocols for the measurement of residual dipolar couplings, in sensitivity optimization of triple-resonance experiments and in detection of hydrogen bonds and in developing computational methods for structure refinement using NMR restraints.
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