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Related Concept Videos

Protein Organization01:13

Protein Organization

Overview
Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to form...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to form...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

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Updated: Jun 29, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

Determination of protein function, evolution and interactions by structural genomics.

S A Teichmann1, A G Murzin, C Chothia

  • 1Department of Biochemistry and Molecular Biology, University College London, Gower Street, WC1E 6BT, London, UK. sat@biochem.ucl.ac.uk

Current Opinion in Structural Biology
|June 19, 2001
PubMed
Summary
This summary is machine-generated.

Genome sequencing enables large-scale protein studies. Experimental and computational structural genomics are advancing the determination of protein function, evolution, and interactions.

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Related Experiment Videos

Last Updated: Jun 29, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

Area of Science:

  • Genomics and Proteomics
  • Structural Biology
  • Bioinformatics

Background:

  • Genome sequencing projects provide comprehensive protein repertoire data.
  • Understanding protein structure, function, and interactions is crucial in biology.
  • Advancements in large-scale techniques are needed for biological research.

Purpose of the Study:

  • To explore new procedures for large-scale determination of protein structure, function, and interactions.
  • To highlight the role of structural genomics in understanding protein characteristics.
  • To showcase the application of experimental and computational approaches in proteomics.

Main Methods:

  • Experimental structural genomics for protein function and evolutionary relationships.
  • Computational structural genomics for discovering protein-protein interactions.
  • Large-scale data analysis from genome sequencing projects.

Main Results:

  • New techniques facilitate large-scale protein structure and function determination.
  • Experimental structural genomics successfully elucidates protein function and evolutionary links.
  • Computational structural genomics effectively identifies protein-protein interactions.

Conclusions:

  • Structural genomics, both experimental and computational, is a powerful approach for characterizing proteins.
  • The integration of genome-wide data with structural genomics drives biological discovery.
  • These methods are essential for advancing our understanding of complex biological systems.