Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Opportunistic Infections: Why Worry?

Abigail L. Smith1

  • 1Loyola University Medical Center, Maywood, Illinois, USA.

ILAR Journal
|June 15, 2001
PubMed
Summary
This summary is machine-generated.

Genetically manipulated rodents require advanced diagnostic methods beyond traditional serology. Molecular diagnostics are crucial for detecting infections in immunocompromised research animals, especially those with altered disease resistance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Laboratory Codes in Nomenclature and Scientific Communication (Advancing Organism Nomenclature in Scientific Communication to Improve Research Reporting and Reproducibility).

ILAR journal·2022
Same journal

History of the National Academies of Sciences, Engineering, and Medicine's Institute for Laboratory Animal Research.

ILAR journal·2022
Same journal

History of the International Council for Laboratory Animal Science.

ILAR journal·2022
Same journal

International Standardized Nomenclature for Outbred Stocks of Laboratory Animals.

ILAR journal·2022
Same journal

Rapid Response by Laboratory Animal Research Institutions During the COVID-19 Pandemic: Key Lessons Learned From a 2021 National Academies of Sciences, Engineering, and Medicine Workshop.

ILAR journal·2022
Same journal

Beyond the Laboratory: Emerging Landscape of Animal Studies - the Influence of National Academies of Sciences Activities and Publications.

ILAR journal·2022
See all related articles

Area of Science:

  • Laboratory animal science
  • Infectious disease diagnostics
  • Genetically modified organisms

Background:

  • Increased use of genetically manipulated rodents strains laboratory animal facilities.
  • Traditional serological testing is standard for immunologically intact animals.
  • Genetic manipulation can lead to unexpected phenotypes, including reduced disease resistance.

Purpose of the Study:

  • To highlight the growing importance of molecular diagnostics in laboratory animal health monitoring.
  • To emphasize the need for advanced diagnostic approaches for genetically modified rodents.

Main Methods:

  • Review of current diagnostic practices in laboratory animal facilities.
  • Discussion of the role of molecular diagnostics in detecting infections.

Related Experiment Videos

  • Analysis of the impact of genetic manipulation on animal health and disease susceptibility.

    • Main Results:

    • Serological testing remains the standard for intact animals.
    • Molecular diagnostics are increasingly vital for immunocompromised animals.
    • Genetic alterations can compromise animal immune systems, increasing infection risk.

    Conclusions:

    • Molecular diagnostics are essential for comprehensive health monitoring of genetically manipulated rodents.
    • Advanced diagnostic strategies are needed to manage the health of research animal populations.
    • Understanding the impact of genetic modification on disease resistance is critical for animal welfare and research integrity.