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Antiprotozoal activity of Neurolaena lobata
I Berger1, C M Passreiter, A Cáceres
1Institut für Pharmakognosie, Universität Wien, Pharmaziezentrum, Althanstrabetae 14, A-1090 Wien, Austria.
Phytotherapy Research : PTR
|June 15, 2001
Abstract:
Extracts, fractions and sesquiterpene lactones from Neurolaena lobata (L.) R. Br. (Asteraceae), a traditional medicinal plant from Guatemala, were tested in vitro against Leishmania spp. promastigotes, Trypanosoma cruzi trypomastigotes and epimastigotes and Trichomonas vaginalis trophozoites. The ethanol extract inhibited the parasite growth of L. mexicana, T. cruzi and T. vaginalis significantly. The pure germacranolides 1 and a mixture of 2 and 3, isolated from the ethonal extract, were highly active against L. mexicana and T. cruzi.