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Related Experiment Videos

C-reactive protein.

S B Rosalki1

  • 1OmniLabs, 27 Harley Street, London W1N 1DA, UK.

International Journal of Clinical Practice
|June 16, 2001
PubMed
Summary
This summary is machine-generated.

C-reactive protein (CRP) indicates inflammation and disease activity. Elevated CRP levels signal increased risk for cardiovascular events and suggest benefits from treatments like aspirin.

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Area of Science:

  • Biochemistry
  • Immunology
  • Clinical Medicine

Background:

  • C-reactive protein (CRP) is an acute-phase protein synthesized by the liver.
  • CRP levels rise in response to inflammatory stimuli, indicating organic disease and disease activity.

Purpose of the Study:

  • To elucidate the diagnostic and prognostic significance of C-reactive protein (CRP).
  • To explore the role of CRP in various clinical conditions and in apparently healthy individuals.

Main Methods:

  • Serum CRP concentrations were measured.
  • Clinical data and patient outcomes were analyzed in relation to CRP levels.

Main Results:

  • High CRP values are associated with bacterial infections, rheumatoid disease, Crohn's disease, myocardial infarction, and trauma.

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  • Elevated CRP in ischemic chest pain predicts an adverse prognosis.
  • In healthy individuals, raised CRP indicates higher risk of atherosclerotic vascular disease.

    • Conclusions:

    • CRP is a valuable biomarker for identifying disease, monitoring activity, and aiding diagnosis.
    • CRP levels provide prognostic information in acute conditions and predict future cardiovascular risk.
    • CRP may identify individuals who benefit from interventions like aspirin and lipid-lowering therapy.