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Olanzapine: another psychotropic?

M P Davis1, E D Dickerson

  • 1Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

The American Journal of Hospice & Palliative Care
|June 16, 2001
PubMed
Summary
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Olanzapine shows potential for treating delirium, psychotic depression, and nausea in advanced cancer patients, offering benefits like weight gain. While costly, reduced hospitalizations may offset expenses.

Area of Science:

  • Oncology
  • Psychiatry
  • Pharmacology

Background:

  • Olanzapine is an atypical antipsychotic with potential applications beyond its primary indications.
  • Advanced cancer patients often experience complex symptoms including delirium, mood disorders, and nausea.
  • Managing these comorbid conditions with a single agent is clinically desirable.

Purpose of the Study:

  • To evaluate the potential of olanzapine as a single-agent therapy for multiple conditions in advanced cancer patients.
  • To identify the benefits and drawbacks of using olanzapine in this patient population.

Main Methods:

  • Literature review of olanzapine's efficacy and safety.
  • Analysis of clinical data regarding symptom management in advanced cancer.

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Main Results:

  • Olanzapine demonstrates potential for treating delirium, psychotic depression, and nausea.
  • Weight gain is a noted additional benefit.
  • The drug has few interactions but a narrow therapeutic window and high cost.
  • A single route of administration is a limitation.
  • Potential for reduced hospitalizations may mitigate cost concerns.

Conclusions:

  • Olanzapine presents a promising, multi-symptom treatment option for advanced cancer patients.
  • Further research is warranted to optimize its use and cost-effectiveness in palliative care.