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Related Experiment Videos

Monophasic transmitral flow pattern with less increase in heart rate indicates left ventricular dysfunction.

K Matsukida1, Y Otsuji, S Hamasaki

  • 1First Department of Internal Medicine, Kagoshima University School of Medicine, Japan.

Japanese Circulation Journal
|June 16, 2001
PubMed
Summary
This summary is machine-generated.

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Elevated heart rate (HR) can cause monophasic mitral flow. This study links prolonged isovolumic contraction time (ICT) and impaired left ventricular (LV) function to monophasic mitral flow at lower HRs, indicating systolic and diastolic dysfunction.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology

Background:

  • Monophasic mitral flow can occur with increased heart rate (HR).
  • Prolonged isovolumic contraction time (ICT) and isovolumic relaxation time (IRT) are linked to left ventricular (LV) function.
  • The relationship between HR triggering monophasic flow and LV function requires investigation.

Purpose of the Study:

  • To investigate the relationship between the heart rate (HR) at which monophasic mitral flow develops and left ventricular (LV) function.

Main Methods:

  • Seventeen patients with normal sinus rhythm underwent diagnostic catheterization.
  • Right atrial pacing incrementally increased HR (2 beats/min every 2 min) until monophasic mitral flow occurred.
  • Left ventricular (LV) function parameters, including ICT, IRT, volumes, ejection fraction, peak positive and negative dP/dt, peak (+dP/dt)/P, and time constant (tau), were measured.

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Main Results:

  • Monophasic mitral flow developed at HRs ranging from 74 to 106 beats/min.
  • Univariate analysis showed significant correlations between monophasic HR and ICT, LV peak +dP/dt, peak (+dP/dt)/P, peak -dP/dt, and tau.
  • Multivariate analysis identified prolonged ICT and reduced LV peak -dP/dt as independent contributors to monophasic mitral flow at lower HRs.

Conclusions:

  • Monophasic mitral flow occurring at a lower HR indicates impaired LV systolic and diastolic function during isovolumic phases.
  • Prolonged ICT and reduced LV relaxation are key indicators of compromised LV function associated with monophasic mitral flow.