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Isolated limb infusion for melanoma: a simple alternative to isolated limb perfusion
R Mian1, M A Henderson, D Speakman
1Bernard O'Brien Institute of Microsurgery, Fitzroy, Victoria, Australia.
Objective:
To describe initial experience with the new technique of isolated limb infusion (ILI) for in-transit melanoma.
Design:
A prospective case series.
Setting:
The major tertiary care oncology centre for the state of Victoria, Australia.
Patients:
Nine patients having for extensive in-transit limb melanoma
Interventions:
All patients received ILI (13 treatments).
Outcome Measures:
Patient survival, response to treatment and complications of treatment.
Results:
There were no perioperative deaths and morbidity was limited to deep venous thrombosis and pulmonary embolism in 1 patient. Control of the in-transit metastases was achieved to some degree in all patients and was complete in 4.
Conclusions:
ILI is an alternative treatment modality for patients suffering from multiple, advanced in-transit melanoma metastases. It provides effective palliation with limited morbidity and offers a safe, quick, inexpensive alternative to isolated limb perfusion with comparable results.