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Mouse models for human familial adenomatous polyposis
R Kucherlapati1, D P Lin, W Edelmann
1Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. kucherla@aecom.yu.edu
Seminars in Cancer Biology
|June 16, 2001
Summary
Colorectal cancer (CRC) is a common cancer. Mouse models are crucial for understanding CRC development and progression, aiding in the identification of key genes involved in this disease.
Area of Science:
- Oncology
- Genetics
- Animal Models
Background:
- Colorectal cancer (CRC) is a leading cause of cancer-related mortality in the Western hemisphere.
- An estimated 150,000 new CRC cases and over 65,000 deaths occur annually in the United States.
- Genetic research has identified key genes involved in CRC initiation and progression.
Purpose of the Study:
- To provide an overview of existing mouse models for colorectal cancer.
- To highlight the contributions of these models to understanding CRC initiation and progression.
Main Methods:
- Review of current literature on colorectal cancer mouse models.
- Analysis of genetic and molecular data from these models.
Main Results:
- Mouse models have been instrumental in elucidating the genetic underpinnings of colorectal cancer.
- These models facilitate the study of tumor initiation, growth, and metastasis.
Conclusions:
- Mouse models are valuable tools for advancing colorectal cancer research.
- Further development and utilization of these models will enhance our understanding of CRC pathogenesis and inform therapeutic strategies.