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Updated: Jul 13, 2026

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
Published on: February 23, 2015
Accelerated functional recovery after neuronal injury by P2 receptor blockade
U Krügel1, H Kittner, H Franke
1Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, Härtelstrasse 16-18, D-04107, Leipzig, Germany. krueu@medizin.uni-leipzig.de
Abstract:
The effect of the P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) on changes of the quantitative electroencephalogram (EEG) after injury of rat brain tissue was investigated. PPADS accelerated the functional recovery from microdialysis probe-induced disturbances in the nucleus accumbens by a decrease of the ratio of absolute slow (0.6-4 Hz) to fast (8-30 Hz) power, mainly caused by a decrease in the delta frequency power. These data provide evidence for a possible neuroprotective effect of P2 receptor antagonists in vivo.

