Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute myeloid leukemia with t(5;18)(q35;q21).

E S Wang1, P Maslak, K Cathcart

  • 1Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University, 1275 York Avenue, New York, NY 10021, USA. wange@mskcc.org

Cancer Genetics and Cytogenetics
|June 16, 2001
PubMed
Summary

This report details a rare case of acute myeloid leukemia associated with a specific chromosomal translocation, t(5;18). This finding expands our understanding of genetic abnormalities in leukemia development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

No evidence for microsatellite instability in acute myeloid leukemia.

Leukemia·2017
Same author

The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia.

Leukemia·2017
Same author

Maintenance therapy with decitabine in younger adults with acute myeloid leukemia in first remission: a phase 2 Cancer and Leukemia Group B Study (CALGB 10503).

Leukemia·2016
Same author

Morphologic identification of atypical chronic lymphocytic leukemia by digital microscopy.

International journal of laboratory hematology·2014
Same author

Molecular epidemiology and risk factors for colonization by vancomycin-resistant Enterococcus in patients with hematologic malignancies.

Infection control and hospital epidemiology·2011
Same author

Biologic features and treatment outcome of secondary acute lymphoblastic leukemia--a review of 101 cases.

Annals of oncology : official journal of the European Society for Medical Oncology·2008

Area of Science:

  • Hematology
  • Cytogenetics
  • Oncology

Background:

  • Cytogenetic abnormalities involving the long arm of chromosome 5 (5q) are recognized contributors to hematopoietic dysfunction.
  • Translocations between chromosome 5q and other chromosomes have been previously linked to various malignancies.

Observation:

  • A unique case of acute myeloid leukemia (AML) is presented, characterized by a specific translocation, t(5;18)(q35;q21).

Findings:

  • This case represents the first documented instance of a t(5;18) translocation directly resulting in the development of acute myeloid leukemia.
  • The study discusses potential molecular mechanisms driving leukemogenesis in this specific genetic context.

Implications:

  • This discovery contributes novel insights into the cytogenetic landscape of acute myeloid leukemia.

Related Experiment Videos

  • Understanding this specific translocation may aid in future diagnostic and therapeutic strategies for AML patients.