Sythesis of polypeptide models of collagen
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Updated: Oct 23, 2026

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen
Published on: September 20, 2012
Abstract:
The synthesis of several sequential oligomer models of collagen is reported. Polytripeptides H(-Pro-Gly-Leu)n OH, H(-Pro-Gly-Phe)n OH, H(-Pro-Sar-Gly)n OH, H-(Sar-Pro-Gly-)n -OH, H(-Pro-Gly-V-AL-)N OH and H(-Gly-Val-Pro)n -oh were synthesized by the active ester method. Preliminary fractionation and mol.wt. determination showed typical gaussian distributions. Good yields were obtained in the mol.wt. range of 4,000-6,000, except in the case of H(-Pro-Sar-Gly-)n OH which yielded molecular weights over 20,000.
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