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2-(4-R-phenoxy/phenylthio)alkanoic esters of l-lupinine
1Istituto di Chimica Farmaceutica e Tossicologica, University of Milan, Viale Abruzzi, 42-I-20131 Milan, Italy. anna.sparatore@unimi.it
Farmaco (Societa Chimica Italiana : 1989)
|June 21, 2001
Abstract:
Considering the great pharmacological interest in phenoxy/phenylthioalkanoic esters of open-chain or cyclic aminoalcohols, a set of ten such esters of lupinine was prepared. Initially, their ability to displace [3H]QNB from rat brain preparation was investigated. With the exception of two, all the prepared esters exhibited good affinity to muscarinic receptors (on a non-selective basis), with pKi in the range 6.67-7.68.