Why did the 5th Earl of Derby die?

W Jeffcoate1

  • 1Department of Diabetes and Endocrinology, City Hospital, NG5 1PB, Nottingham, UK. jeffcoate@bigfoot.com

PubMed

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Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
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Autophagic Cell Death

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