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Updated: Oct 7, 2026

Methods to Enable Spatial Transcriptomics of Bone Tissues
Published on: May 3, 2024
Spectroscopic imaging of bone marrow composition in vertebral bodies
1Department of Oncology, Radiology and Clinical Immunology, Uppsala University Hospital, Uppsala, Sweden. jan.weis@mta.uas.lul.se
Abstract:
The proton spectroscopic imaging technique that uses read gradient during acquisition was used for the measurement of the proton spectra in the lumbar and thoracic part of the spine of a patient with breast cancer without known skeletal metastases. The bone marrow fat/water ratios were evaluated in the same location before and after chemotherapy treatment. The results were corrected for relaxation effects. The fat/water ratios showed a significant increase as a consequence of the bone marrow degradation process due to chemotherapy. The proposed spectroscopic imaging technique offers rapid acquisition of proton spectra from large volumes of the vertebral bodies.
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