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Updated: Aug 5, 2026
07:24
Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
Published on: April 8, 2013
Left ventricular dysfunction, natriuretic peptides, and mortality in an urban population
T A McDonagh1, A D Cunningham, C E Morrison
1Department of Medical Cardiology, University of Glasgow, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK. t.mcdonagh@bio.gla.ac.uk
Heart (British Cardiac Society)
|June 19, 2001
Summary
Left ventricular systolic dysfunction (LVD) significantly increases mortality risk. Brain natriuretic peptide (BNP) levels independently predict outcomes, offering prognostic value beyond diagnosis.
Area of Science:
- Cardiology
- Biomarkers
- Public Health
Background:
- Left ventricular systolic dysfunction (LVD) is a critical condition affecting heart function.
- Natriuretic peptide hormones, including N-terminal atrial natriuretic peptide (N-ANP) and brain natriuretic peptide (BNP), are implicated in cardiovascular regulation.
- Understanding the prognostic implications of LVD and natriuretic peptides is crucial for patient management.
Purpose of the Study:
- To determine the mortality associated with LVD, assessed by echocardiography.
- To investigate the relationship between natriuretic peptide hormones (N-ANP and BNP) and mortality in a general urban population.
- To identify independent predictors of all-cause mortality in relation to LVD and natriuretic peptides.
Main Methods:
- Echocardiography was used to measure left ventricular ejection fraction (LVEF) in 1640 participants.
- LVD was defined as LVEF ≤ 30%.
- Plasma N-ANP and BNP concentrations were measured, and mortality was tracked over four years.
Main Results:
- Four-year all-cause mortality was 4.9% in the cohort, significantly higher (21%) in those with LVEF ≤ 30%.
- Elevated BNP and N-ANP levels were strongly associated with increased mortality.
- Multivariate analysis identified age, BNP concentration (≥ 17.9 pg/ml), ischemic heart disease, and male sex as independent predictors of mortality.
Conclusions:
- LVD is linked to substantial mortality in the studied urban population.
- BNP serves as an independent predictor of mortality, providing prognostic information.
- BNP levels help clarify the prognosis associated with a given degree of LVD, complementing diagnostic assessments.
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