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Updated: Oct 7, 2026
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Viable myocardium in reperfused acute myocardial infarction: rest and stress first-pass mr imaging
K I Chung1, T S Chung, R D White
1Department of Diagnostic Radiology, Ajou University Hospital, Suwon, Korea. chki@madang.ajou.ac.kr
Abstract:
Feasibility of identifying viable myocardium in rest and stress magnetic resonance imaging (MRI) was evaluated using 3 hr occlusion and 30 min reperfusion model of left anterior descending (LAD) coronary artery in 12 felines. At rest MRI, viable myocardium confirmed by 2,3,5-triphenyl tetrazolium chloride (TTC)-staining showed rapid signal intensity (SI) rise followed by gradual decline not significantly different from normal myocardium that the two hyperperfused regions were distinguishable only from the hypoperfused nonviable myocardium. At stress MRI, hyperemia induced perfusion change was most pronounced in normal myocardium with earlier and greater peak enhancement followed by brisk 'washout' phase while minimally augmented enhancement in viable myocardium was still in 'washin' phase. From these findings, it was concluded that viable myocardium is identified in rest and stress MRI as redistributing hypo- perfusion compared to persistent hyper-perfusion of the normal myocardium and the persistent hypo-perfusion of the nonviable myocardium.
Insights
Rest and stress cardiac MRI can identify viable myocardium by detecting changes in blood flow. Viable tissue shows redistribution of perfusion, unlike normal or nonviable myocardium.
Area of Science:
- Cardiovascular Imaging
- Myocardial Perfusion Imaging
- Magnetic Resonance Imaging
Background:
- Assessing myocardial viability is crucial for guiding treatment decisions in ischemic heart disease.
- Magnetic Resonance Imaging (MRI) offers a non-invasive method to evaluate myocardial perfusion.
Purpose of the Study:
- To evaluate the feasibility of identifying viable myocardium using rest and stress cardiac MRI.
- To characterize perfusion patterns of viable, normal, and nonviable myocardium in a feline model.
Main Methods:
- A 3-hour occlusion and 30-minute reperfusion model of the left anterior descending coronary artery was used in 12 felines.
- Rest and stress cardiac MRI were performed, with findings compared to 2,3,5-triphenyl tetrazolium chloride (TTC) staining for viability.
- Signal intensity (SI) changes and perfusion dynamics were analyzed.
Main Results:
- At rest MRI, viable myocardium showed a rapid SI rise and gradual decline, similar to normal myocardium.
- Stress MRI revealed pronounced hyperemia and rapid 'washout' in normal myocardium.
- Viable myocardium exhibited minimally augmented enhancement and was still in the 'washin' phase during stress, distinguishing it from persistently hyperperfused normal and hypoperfused nonviable myocardium.
Conclusions:
- Rest and stress cardiac MRI can differentiate viable myocardium based on perfusion patterns.
- Viable myocardium is identified as having redistributing hypoperfusion.
- This technique distinguishes viable from persistently hyperperfused normal and hypoperfused nonviable myocardium.
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