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Histological changes in the cervical lymph nodes after radiotherapy.

J Shvero¹, R Koren, G Marshak

¹Department of Otolaryngology, Beilinson Hospital, Petah Tikva, Israel.

Oncology Reports

|June 19, 2001

Summary

Neck radiotherapy for cancer causes histopathological changes. Long-term effects show more fibrosis and vascular changes, with lymph nodes shrinking significantly over six years, indicating radiosensitivity.

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Area of Science:

Oncology
Pathology
Radiology

Background:

Neck radiotherapy is a common cancer treatment, often combined with surgery or chemotherapy.
Histopathological changes in neck tissues post-radiotherapy require detailed investigation.

Purpose of the Study:

To analyze and compare short-term and long-term histopathological changes in the neck after radiotherapy.
To evaluate the radiosensitivity of lymph nodes based on size.

Main Methods:

Histopathological examination of neck tissues from patients treated with radiotherapy.
Categorization of changes into short-term (6 months-1 year) and long-term (over 6 years) groups.
Comparison with a control group that did not receive radiotherapy.

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Main Results:

Long-term radiotherapy exposure resulted in more pronounced stromal fibrosis and vascular changes compared to short-term exposure.
Lymph nodes measuring over one centimeter in the long-term group were significantly smaller than in the short-term group.
The findings suggest lymph nodes larger than one centimeter are more radiosensitive.

Conclusions:

Radiotherapy induces progressive histopathological changes in neck tissues over time.
Larger lymph nodes exhibit greater radiosensitivity, shrinking significantly after six years of radiotherapy treatment.