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[Drug induced pulmonary hypertension]
1Division of Cardiology and Pulmonary Circulation, Department of Medicine, National Cardiovascular Center.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|June 20, 2001
Summary
Primary pulmonary hypertension (PPH) is a rare, fatal condition more common in women. Research links appetite suppressant drugs to PPH development, though the exact mechanism remains unclear.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Epidemiology
Context:
- Primary pulmonary hypertension (PPH) is a rare, often fatal condition with unknown causes.
- PPH disproportionately affects women.
- Previous research has implicated toxins and drugs in the development of pulmonary hypertension (PH).
Purpose:
- To explore the association between anorectic drugs and the development of primary pulmonary hypertension (PPH).
- To investigate the potential causative role of appetite suppressants in PPH pathogenesis.
Summary:
- An epidemic of PH in the 1960s was linked to the anorexic agent aminorex.
- The International Primary Pulmonary Hypertension Study (IPPHS) identified a strong association between PPH and appetite suppressant use.
- The precise mechanism by which anorectic drugs induce PH is currently unknown.
Impact:
- Highlights the potential iatrogenic risks associated with appetite suppressant medications.
- Underscores the need for further research into the specific mechanisms of drug-induced pulmonary hypertension.
- Informs clinical awareness and patient counseling regarding the potential cardiovascular risks of certain medications.