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Related Experiment Videos

Catecholamines in human saliva.

B Kennedy1, E Dillon, P J Mills

  • 1Department of Medicine, University of California, San Diego Medical Center, 92103, USA. bpkennedy@ucsd.edu

Life Sciences
|June 20, 2001
PubMed
Summary
This summary is machine-generated.

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Norepinephrine (NE) in human saliva originates from both the bloodstream and local sympathetic nerves. Saliva NE levels reflect blood NE but with a delay, making it a poor indicator of rapid sympathetic nervous system changes.

Area of Science:

  • Physiology
  • Neuroscience
  • Biochemistry

Background:

  • Catecholamines, including norepinephrine (NE), are present in human saliva.
  • The precise origin of salivary catecholamines remains unclear.

Purpose of the Study:

  • To investigate the origin of norepinephrine (NE) in human saliva.
  • To determine the relationship between salivary NE and plasma NE levels.
  • To assess the stability and influencing factors of NE in saliva.

Main Methods:

  • Intravenous infusion of 3H-NE in humans.
  • Measurement of 3H-NE and metabolites in saliva and forearm venous plasma.
  • Analysis of NE and epinephrine (E) ratios.
  • Assessment of NE stability at different temperatures.

Related Experiment Videos

  • Evaluation of NE levels under conditions of chewing and posture changes.

    • Main Results:

    • 3H-NE levels in saliva increased for 1 hour post-infusion, while plasma levels plateaued by 5 minutes.
    • The ratio of 3H-NE to non-radioactive NE in saliva matched plasma levels after 65 minutes.
    • NE and epinephrine ratios were consistent between saliva and plasma.
    • Chewing increased NE, E, and 3H-NE release but decreased their concentration in saliva.
    • Upright posture increased salivary NE levels after 1 hour.

    Conclusions:

    • Salivary NE originates from both systemic circulation and local sympathetic nerve activity.
    • Blood NE diffusion into saliva takes approximately 1 hour.
    • Salivary NE is not a reliable marker for acute fluctuations in sympathetic activity.