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Naproxen particle design using porous starch.

K Nagata1, H Okamoto, K Danjo

  • 1Faculty of Pharmacy, Meijo University, Nagoya, Japan.

Drug Development and Industrial Pharmacy
|June 20, 2001
PubMed
Summary

Preferential grinding effectively embeds naproxen into porous starch (PS) particles, enhancing drug content and dissolution rates without altering naproxen

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Area of Science:

  • Materials Science
  • Pharmaceutical Technology
  • Drug Delivery Systems

Background:

  • Porous starch (PS) is a promising excipient for drug formulation.
  • Efficiently embedding active pharmaceutical ingredients (APIs) like naproxen into porous starch is crucial for improved drug delivery.
  • Understanding the physicochemical properties and drug-API interactions is key to optimizing formulation.

Purpose of the Study:

  • To investigate the physicochemical properties of naproxen-loaded porous starch particles prepared by preferential grinding.
  • To evaluate the impact of different grinding methods (Mechanofusion vs. Mechanomill) on naproxen content and drug-excipient interactions.
  • To assess the effect of preferential grinding on the dissolution rate of naproxen from porous starch particles.

Main Methods:

  • Preparation of porous starch (PS) particles loaded with naproxen using preferential grinding (Mechanofusion and Mechanomill).
  • Characterization of particle properties including pore diameter and pore volume using mercury porosimetry.
  • Analysis of naproxen crystallization state and drug-excipient interactions using powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC).
  • Evaluation of naproxen dissolution rates from prepared particles and physical mixtures.

Main Results:

  • Porous starch particles prepared by preferential grinding with Mechanofusion exhibited higher naproxen content compared to those prepared with Mechanomill.
  • No significant changes in the crystallization state of naproxen or interactions between naproxen and porous starch were observed.
  • The dissolution rate of naproxen from particles prepared by preferential grinding was significantly faster than from physical mixtures.

Conclusions:

  • Preferential grinding is an effective method for loading naproxen into porous starch, enhancing drug content and dissolution.
  • The Mechanofusion system offers superior performance for naproxen embedding in porous starch compared to the Mechanomill.
  • The developed naproxen-porous starch formulations show potential for improved oral drug delivery due to enhanced dissolution characteristics.

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