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Updated: Jul 12, 2026

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

Evolving indications for permanent pacemakers.

M Bryce¹, S R Spielman, A M Greenspan

¹Albert Einstein Medical Center, Division of Cardiovascular Diseases, 5401 Old York Road, Klein Building, Suite 363, Philadelphia, PA 19141, USA.

Annals of Internal Medicine

|June 20, 2001

Summary

Permanent cardiac pacing offers new therapeutic options for conditions like hypertrophic obstructive cardiomyopathy, heart failure, and syncope. While promising, ongoing trials are needed to confirm long-term benefits and mortality improvements.

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Area of Science:

Cardiology
Medical Devices
Clinical Trials

Background:

Permanent cardiac pacing is increasingly indicated for various cardiovascular disorders.
Clinicians must be aware of evolving pacing therapies for common conditions.

Purpose of the Study:

To review new indications for permanent cardiac pacing.
To assess the clinical outcomes and therapeutic potential of pacing in specific heart conditions.

Main Methods:

Review of observational studies and clinical trials on cardiac pacing.
Analysis of pacing's efficacy in hypertrophic obstructive cardiomyopathy, dilated cardiomyopathy, heart failure, neurocardiogenic syncope, and atrial fibrillation prevention.

Main Results:

Observational data suggest symptomatic and hemodynamic improvement with pacing in hypertrophic obstructive cardiomyopathy.
Pacing shows potential as an adjunctive therapy for dilated cardiomyopathy and heart failure, though mortality benefit is unproven.
Rate-drop sensor algorithms may benefit neurocardiogenic syncope patients.
Biatrial pacing shows promise in preventing atrial fibrillation; multisite atrial pacing is investigational.

Conclusions:

New cardiac pacing indications offer potential clinical benefits for multiple heart conditions.
Further randomized trials are essential to establish long-term efficacy and mortality benefits.
Pacing is an evolving therapeutic strategy with promising, yet not fully established, roles in cardiovascular medicine.