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Autoimmunity against the ryanodine receptor in myasthenia gravis
G O Skeie1, P K Lunde, O M Sejersted
1Department of Neurology, University of Bergen, Bergen, Norway.
Acta Physiologica Scandinavica
|June 20, 2001
Abstract:
Some myasthenia gravis (MG) patients have antibodies against skeletal muscle antigens in addition to the acetylcholine receptor (AChR). A major antigen for these antibodies is the Ca2+ release channel of the sarcoplasmic reticulum the ryanodine receptor (RyR). These antibodies are found mainly in MG patients with a thymoma MG and correlate with severe MG symptoms. The antibodies recognize a region near the N-terminus on the RyR, which seems to be of importance for RyR regulation. The antibodies cause allosteric inhibition of RyR function in vitro, inhibiting Ca2+ release from sarcoplasmic reticulum.