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[Apolipoprotein E polymorphism and coronary disease].

R Peña1, J M Mostaza, C Lahoz

  • 1Unidad de Arteriosclerosis. Hospital Carlos III. Madrid.

Medicina Clinica
|June 20, 2001
PubMed
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The study found that individuals carrying the apolipoprotein E (ApoE) *4 allele have a significantly higher prevalence of coronary artery disease in Spain. This association remained strong even after adjusting for various cardiovascular risk factors.

Area of Science:

  • Genetics and cardiovascular disease research
  • Atherosclerosis and lipid metabolism
  • Population genetics of Apolipoprotein E

Context:

  • Apolipoprotein E (ApoE) is crucial in atherogenesis.
  • ApoE exhibits genetic polymorphism with alleles *2, *3, and *4.
  • Hypercholesterolemia is a significant risk factor for cardiovascular disease.

Purpose:

  • To investigate the association between the ApoE *4 allele and coronary heart disease (CHD).
  • To evaluate this association in a cohort of hypercholesterolemic Spanish subjects.

Summary:

  • The study analyzed 389 hypercholesterolemic subjects, determining their ApoE genotypes.
  • Prevalence of coronary artery disease was 15.7% in *4 allele carriers versus 6.9% in non-carriers.
  • The association between the ApoE *4 allele and higher CHD prevalence remained significant after logistic regression analysis.

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Impact:

  • Findings suggest the ApoE *4 allele is a risk factor for coronary artery disease in the Spanish population.
  • This highlights the importance of ApoE genotyping in cardiovascular risk assessment.
  • Contributes to understanding the genetic determinants of atherosclerosis in diverse populations.