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[Current topics in vascular biology: an update for the 21st century]
1Department of Internal Medicine, and Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill. Chapel Hill. North Carolina. EE.UU. cpatters@med.unc.edu
Insights
Vascular biology research reveals the critical role of blood vessels in cardiovascular health and disease. Key areas include oxidative stress, blood vessel growth (angiogenesis), and atherosclerosis biomarkers, impacting future patient care.
Area of Science:
- Cardiovascular science
- Vascular biology
- Physiology and pathology
Context:
- The significance of blood vessels in cardiovascular regulation is a recent discovery.
- Vascular biology has emerged as a crucial field due to the vasculature's role in cardiovascular diseases.
Purpose:
- To provide an update on key areas within vascular biology.
- To highlight advancements in oxidative stress, angiogenesis, and atherosclerosis biomarkers.
Summary:
- Reviews the role of oxidative stress in vascular function and dysfunction.
- Discusses angiogenesis and the potential of angiogenic gene therapies.
- Explores emerging biomarkers for atherosclerosis detection and management.
Impact:
- Advances in these areas are expected to significantly influence clinical decisions.
- Future research will directly improve the care of patients with cardiovascular diseases.
Abstract:
Although taken for granted in the present day, the central role played by the blood vessels themselves in regulating the cardiovascular system under physiologic and pathologic conditions has only been understood in the last several decades. The field of vascular biology grew out of this appreciation of the primacy of the vasculature in cardiovascular pathologies. In this review, we come up to date on several topics of particular interest to the field of vascular biology as it enters the 21st century: namely, the role of oxidative stress in vascular function and dysfunction; angiogenesis and angiogenic gene therapies; and emerging biomarkers of atherosclerosis. Each of these areas is likely to experience significant advances in the coming years that will directly impact clinical decision-making and care of patients with cardiovascular diseases.