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[Sympathetic control mechanisms during general anesthesia].

P Kienbaum1, J Peters

  • 1Abteilung für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Essen. peter.kienbaum@uni-essen.de

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
|June 21, 2001
PubMed
Summary
This summary is machine-generated.

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Anesthetics like etomidate and ketamine minimally impact sympathetic nervous system activity. These agents are recommended for patients with heightened sympathetic outflow to maintain blood pressure during anesthesia.

Area of Science:

  • Cardiovascular physiology
  • Autonomic nervous system research
  • Anesthesiology

Context:

  • The sympathetic nervous system regulates cardiovascular function.
  • Muscle sympathetic activity is a key indicator of sympathetic neural outflow.
  • Anesthesiologists evaluate anesthetic effects on sympathetic activity.

Purpose:

  • To review the impact of various anesthetics on muscle sympathetic activity.
  • To identify anesthetic agents that least depress sympathetic outflow.
  • To guide anesthetic selection in patients with activated sympathetic outflow.

Summary:

  • Positive pressure ventilation, intravenous, and inhalational anesthetics affect sympathetic muscle outflow.
  • Etomidate, ketamine, or low-dose isoflurane/nitrous oxide/opioids show the least sympathetic depression.

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  • These agents preserve resting sympathetic outflow and response to challenges.

    • Impact:

    • Recommends specific anesthetics for patients requiring maintained arterial blood pressure.
    • Informs anesthetic choices for individuals with elevated sympathetic nervous system activity.
    • Contributes to safer anesthetic management in critical care settings.