[Hematopoietic stem cell transplantation after nonmyeloablative conditioning]

In these last years it has become evident that nonmyeloablative stem cell transplantation (NST) is a feasible procedure at least in the first 100 days. Generally NST has less severe adverse effects than conventional allografting. Unfortunately, short observation period cannot permit us to give a definitive reply to the question if this procedure will substitute the conventional myeloablative transplantation. NST is a promising new option for the treatment of hematologic and non-hematologic neoplasia, which role will be better defined in the near future.