Behaviour of commercially prepared I-125 fibrinogen in metabolic studies

In-vivo studies of fibrinogen metabolism were carried out using an I-120 labelled preparation of fibrinogen supplied commercially by the Radiochemical Centre, Amerhsham for use in the diagnosis of deep venous thrombosis. These studies show that the material is suitable for obtaining the main metabolic parameters of clinical interest, though degradation products may be present initially or appear during storage. If suitable corrections are applied the results agree well with those of other authors.