Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Codon distributions in DNA.

A Som1, S Chattopadhyay, J Chakrabarti

  • 1Department of Theoretical Physics, Indian Association for the Cultivation of Science, Calcutta 700 032, India. tpas@mahendra.iacs.res.in

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|June 21, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular Signatures of Senescence in Periodontitis: Clinical Insights.

Journal of dental research·2024
Same author

Hot crystals of thermo-responsive particles with temperature dependent diameter in the presence of a temperature gradient.

The Journal of chemical physics·2023
Same author

Conformational fluctuations in the molten globule state of α-lactalbumin.

Physical chemistry chemical physics : PCCP·2022
Same author

Impact of COVID-19 on CT-diagnosed acute appendicitis and diverticulitis: was there collateral damage?

Clinical radiology·2022
Same author

Viscoelastic response of fluid trapped between two dissimilar van der Waals surfaces.

Journal of physics. Condensed matter : an Institute of Physics journal·2022
Same author

A long-range order in a thermally driven system with temperature-dependent interactions.

Soft matter·2022
Same journal

Tension on dsDNA bound to ssDNA-RecA filaments may play an important role in driving efficient and accurate homology recognition and strand exchange.

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Amplitude-phase coupling drives chimera states in globally coupled laser networks [Phys. Rev. E 91, 040901(R) (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Erratum: Shapes of sedimenting soft elastic capsules in a viscous fluid [Phys. Rev. E 92, 033003 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Erratum: Attenuation of excitation decay rate due to collective effect [Phys. Rev. E 90, 022142 (2014)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells [Phys. Rev. E 92, 052715 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
Same journal

Publisher's Note: Lattice Boltzmann approach for complex nonequilibrium flows [Phys. Rev. E 92, 043308 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016
See all related articles

DNA codon distribution is nearly universal across genes, with a calculable gene-independent component. A small, gene-specific portion remains with undetermined fluctuations.

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • DNA sequences contain 64 codons, which are fundamental units of genetic information.
  • The distribution of these codons within coding regions exhibits complex patterns.
  • Previous studies noted near-universal characteristics in codon distributions, suggesting underlying biological principles.

Purpose of the Study:

  • To develop a theoretical framework for understanding DNA codon distribution.
  • To differentiate between universal and gene-specific components of codon frequency.
  • To provide a method for calculating the gene-independent part of codon distribution.

Main Methods:

  • Analysis of codon frequency and rank in DNA sequences.
  • Development of a theoretical model to explain universal codon distribution parameters.

Related Experiment Videos

  • Characterization of gene-specific variations in codon usage.

    • Main Results:

    • Identified a significant universal (gene-independent) component in codon distribution.
    • Quantified parameters that characterize this universal component.
    • Observed that only a small fraction of codon distribution is gene-specific.

    Conclusions:

    • The near-universality of DNA codon distribution is largely explained by a calculable gene-independent factor.
    • Gene-specific variations in codon usage represent a smaller, more complex component.
    • The presented theory offers insights into the fundamental principles governing genetic code organization.