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Lipogenesis in rabbit adipose tissue.

S Smith

    Journal of Lipid Research
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Rabbit adipose tissue efficiently synthesizes fatty acids from pyruvate and acetate, unlike glucose. This highlights unique lipogenesis pathways in rabbits, distinct from other mammals.

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    Area of Science:

    • Biochemistry
    • Metabolic pathways
    • Animal physiology

    Background:

    • Previous studies suggested limited fatty acid synthesis in rabbit adipose tissue.
    • Understanding lipogenesis and glyceroneogenesis is crucial for metabolic research.

    Purpose of the Study:

    • To investigate the pathways of lipogenesis and glyceroneogenesis in rabbit adipose tissue.
    • To determine the capacity for de novo fatty acid synthesis from various substrates.

    Main Methods:

    • Enzyme inhibition studies using hydroxycitrate.
    • Analysis of metabolic flux from glucose, pyruvate, and acetate.
    • Investigation of gluconeogenic pathways and the dicarboxylic acid shuttle.

    Main Results:

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  • Rabbit adipose tissue exhibits low de novo fatty acid synthesis from glucose.
  • High capacity for fatty acid synthesis from pyruvate and acetate was observed.
  • Pyruvate conversion to glyceride-glycerol via gluconeogenic pathways is significant.
  • Citrate cleavage enzyme is obligatory for lipogenesis from pyruvate.

    • Conclusions:

    • Rabbit adipose tissue lipogenesis is adapted to utilize acetate and pyruvate, similar to ruminants.
    • Limited glucose utilization for fatty acid synthesis is due to a block before pyruvate, likely at hexokinase and pyruvate kinase.
    • Metabolic pathways in rabbit adipose tissue differ from typical mammalian models.