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Published on: November 4, 2011
Electroretinogram and cue-elicited craving in withdrawn cocaine-dependent patients: a replication
1Department of Veterans Affairs, New Jersey Health Care System, Lyons 07939-5000, USA.
Background:
We previously reported that cocaine-dependent patients with a reduced blue cone b wave electroretinogram (ERG) responses had significantly more cue-elicited craving.
Methods:
A new series of 21 recently withdrawn cocaine-dependent patients completed a craving questionnaire at baseline and following cue exposure; an ERG was also performed.
Results:
Cocaine-dependent patients with a blunted ERG blue cone response (<0.5 microV) showed greater increases in craving following cue exposure. When subjects were included from our preliminary study (N = 14), these differences became highly significant.
Conclusions:
Patients with a reduced ERG response may represent a subgroup more vulnerable to cocaine craving and future relapse.
